Once you've installed phpList Version 2... ask questions here!
Forum rules
Please help the volunteers to help you by supplying the version of phpList you are using, browser & version and if possible, a link to your phpList installation. This is for Version 2 of phpList (the orange one).
The location to change the SMTP settings can be found in the lists/config/config.php file.
Around about lines 696-704 and change the existing settings to those used by your new email settings. Don't forget to remove the # from the start of the "define" lines if you are starting afresh and wish to use those particular settings.