yes... you need to configure the system for command line processing.
basic instructions are at the bottom of this page:
http://resources.phplist.com/documentat ... ngcampaignyou need to edit your config.php to allow for command line processing (and also change your settings to send 200 emails per hour in config.php), and also setup a cron job that processes your queue, and processes the bounces, via a command line.